2,3-Diaryl-substituted indole based COX-2 inhibitors as leads for imaging tracer development

2,3-Diaryl-substituted indole based COX-2 inhibitors as leads for imaging tracer development

Department Radiopharmaceutical and Radiopharmaceutical Cancer Research, H 01328 Dresden, Germany. E-mail: t.kn +493512602760; +493512602622 Department of Chemistry and Food Che 01062 Dresden, Germany Department of Oncology, Cross Cancer In Alberta, Canada T6G 1Z2 Centre for Translational Bone, Joint, and S University Hospital, Technische Universität, Department of Inorganic Solid State Chemi Ro...

recent advances in drug development: design, synthesis and biological evaluation of substituted 2-alkylthio-1,5-diaryl-imidazoles as selective cox-2 inhibitors

synthesis of new 2,5-diaryl 1,3,4-oxadiazole derivatives as selective cox-2 inhibitors

Quantitative structure activity relationship studies of diaryl furanones as selective COX-2 inhibitors.

Selective COX-2 inhibitors have attracted much attention in recent times in the design of non-steroidal anti-inflammatory agents (NSAID), which are devoid of the common side effects of classical NSAIDs. QSAR studies have been performed on a series of diaryl furanones that acts as selective COX-2 inhibitor using Molecular Operating Environment (MOE). The studies were carried out on 43 analogs. T...

Synthesis of diaryl-substituted imidazo[l,2-a]pyridines designed as potential aromatase inhibitors.

From a pharmacophore model of bicyclic heterocycles as aromatase inhibitors we have designed three series of imidazo[1,2-a]pyridine derivatives. The synthesis and the spectroscopy determination of various compounds are reported. The crystal data of one of these compounds (10b) was obtained. The aromatase inhibition potency was evaluated in vitro and no activity was found.